C: Use with caution if Added benefits outweigh threats. Animal research present possibility and human scientific tests not available or neither animal nor human studies carried out.
pentobarbital increases effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Keep an eye on. Coadministration of ifosfamide with CYP2B6 inducers may possibly raise metabolism of ifosfamide to its metabolite. Monitor for improved effects/toxicities if blended with CYP2B6 inducers.
pentobarbital will minimize the level or outcome of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. The efficacy of hormonal contraceptives could be decreased.
pentobarbital will decrease the extent or impact of vardenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital decreases amounts of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration with powerful CYP3A4 inducers; these drugs minimize exposure to vandetanib by nearly 40%.
fentanyl intranasal and pentobarbital both equally increase sedation. Keep away from or Use Alternate Drug. Restrict use to individuals for whom alternative treatment method choices are inadequate
pentobarbital will minimize the extent or result of quinidine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
lasmiditan, pentobarbital. Both raises effects of another by sedation. Use Caution/Keep track of. Coadministration of lasmiditan and other CNS depressant drugs, including Liquor haven't been evaluated in medical reports. Lasmiditan may perhaps bring about sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
pentobarbital will minimize the extent or influence more info of sunitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will lessen the extent or influence of aprepitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will lower the level or influence of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will minimize the extent or impact of ondansetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. No dosage adjustment for ondansetron is suggested for patients on these drugs.
pentobarbital will decrease the extent or outcome of rolapitant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Extensive-term coadministration of robust CYP3A4 inducers with rolapitant may perhaps drastically lower rolapitant efficacy.
pentobarbital will lessen the level or effect of zaleplon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Mysterious.